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HNF1B Mutation probability calculator

Based on advanced machine learning algorithms and giving high quality end results!

Calculate probability and compare models!

By the selection of the checkboxes and entering the value of Your patient's serum potassium concentration you can calculate the probability of HNF1B mutation according to our Random Forest predictive model. Additionally our application enables the calculation of Faguer's score and comparison with Random Forest model.

  • Provide all values!
  • If the checkbox is not selected, it means that Your patient does not have the corresponding trait
  • Provide the serum potassium concentration in mmol/l. If you have another unit of measurment in your data, check out the calculator here!
  • Select the model by choosing corresponding checkbox!
  • For the calculation of Faguer's score you have to provide some additional data!

Choose output type!

You can get your results either as cleanly generated PDF or online at our website

  • Check the option by selecting appropriate checkbox
  • If you check PDF option, the results will be downloaded after clicking the 'Submit' button
  • If you choose Online option, you will be redirected to website wit the results of your patient

RANDOM FOREST CALCULATOR SECTION

Random Forest Parameters

Select the checkbox if Your patient has the corresponding trait

sK
mmol/L

Choose model and output type

By selecting the checkboxes you can decide which model you choose and which output type you prefer

Disclaimer This prediction model and its corresponding calculator have been derived from a cohort of children and young adults with CAKUT with normal or mildly compromised kidney function. Therefore, the assessment of the presence of HNF1B mutation may not be applicable to adults or those with more advanced kidney failure. Please refer to the original publication for detailed characteristics of the population used for model discovery. It Is important to note that this tool has not been externally validated, thus we recommend treating each patient individually. Besides from the abovementioned abnormalities, an assessment of a patient should include an evaluation of other extrarenal features that may provide information about the presence of HNF1B mutation.

This calculator is designed to assess the probability of HNF1B mutation in a child presenting with congenital anomalies of the kidneys and urinary tract (CAKUT). The calculation is based on a random forest model, which includes hypermagnesuria (FEMg > 5%), hypomagnesemia, bilateral kidney anomaly, pancreas malformation, and serum potassium level. In order to achieve a good model performance, we highly recommend the use of age-dependent lower limits for serum Mg (references below) to define hypomagnesemia, as well as detailed sonographic assessment of both kidneys (length, presence of cysts, echogenicity, cortico-medullary differentiation) and the pancreas.